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KMID : 0616120070380040376
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.376 ~ p.381
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Isolation of Melanin Biosynthesis Inhibitory Compounds from the Seeds of Plantago asiatica L.
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Oh Joon-Seok
Lee Seung-Ho
Son Jong-Keun
Choi Ji-Young
Choi Een-Hyang
Jung Hee-Wook
Kim Dong-Chun
Lee Jong-Koo
Kim Jeong-Ah
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Abstract
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Seven compounds were isolated from the MeOH extract of the seeds of Plantago asiatica L. and their structures were identified as β-sitosterol (1), (24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one (2), acteoside (3), geniposidic acid (4), 1-octen-3-ol 3-O-β-D-xylopyranosyl(1→6)-β-D-glucopyranoside (5), plantainoside D (6) and plantamajoside (7) on the spectroscopic analysis. Among them, (24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one (2) and 1-octen-3-ol 3-O-β-D-xylopyranosyl (1→6)-β-D-glucopyranoside (5) were first isolated from this plant. Among them, geniposidic acid (4) showed the most potent inhibitory effect on melanogenesis, with inhibition rate of 41%.
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KEYWORD
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Plantago asiatica L., melanogenesis inhibitory effect, geniposidic acid
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